The Po Valley has had traces of inhabitation since at least 780,000 years ago, when the first big glaciation of pleistocene took place. Sites like Monte Poggiolo may have served as refuges of human populations fleeing the terribly cold conditions of northern Europe during the subsequent glaciations along pleistocene [14] The valley was covered by sea level in warm times, but glaciations could cause a lower sea level that allowed big mammals and humans to migrate from Africa and the Middle East to central and western Europe through an empty and open Po valley, avoiding the barrier of the Alps, reaching the Loire Valley, and Iberian Peninsula, and then, when glaciation retreated, the rest of continental Europe.

Urban development began in the Po Valley much later than in southern Italy or Greece. The first known ancient inhabitants of the thick forests and swamps were the Ligurians, an Indo-European race of people. After the progressive immigration in the 7th century BC of Celtic peoples known as the Insubres (hence the name of Insubria sometimes being given to northwestern Lombardy), the southern and central regions were conquered and colonised here and there by a pre-Indo-European people, the Etruscans, who left names such as Parma, Ravenna and Felsina, the ancient name of Bologna. The Etruscan domination left significant marks and introduced urban civilisation, but was short-lived. As the 5th century BC dawned, a new Celtic horde swarmed through the passes of the Western Alps and conquered most of the Po Valley. This invasion from the north did not reach Veneto …

Source: Po Valley – Wikipedia